FHU ADAPT

Improve the prognosis of mental disorders and addictions
by identifying stratification biomakers defining homogeneous entities
to pave the way for precision psychiatry.

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Projects calls

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Institution :
FLAG-ERA

int Transnational Call 2021: HBP Research and Innovation

The projects should propose holistic approaches combining computer sciences and neurosciences to address at least one of the following aims:

  1. Studying genotype-phenotype relationships related to Brain Function. Research projects aiming to establish the relationship between genetics and phenotype are essential to understand the causality relationship between identified mutations and brain dysfunction or functional compensation leading to resilience.
    Research projects dealing with anatomical (micro, meso, macroscales, molecular and cellular type maps) as well as functional phenotypes (behavior, functional connectome, etc) in animal models as well as in large human cohorts are eligible. The projects are encouraged to address non-genetic determinants of variability among individuals.
  2. Accelerating the diagnosis and the development of therapeutic approaches for rare diseases affecting the nervous system. Research projects using holistic approaches and computational tools to develop, accelerate or improve diagnostic and therapeutic approaches for rare diseases3 affecting the nervous system. Clinical and preclinical proposals making use of available medical or preclinical datasets for analysis, modelling or simulation studies are eligible.
  3. Tackling Psychiatric Diseases. Research projects developing diagnostic, patients stratification or treatment strategies for Psychiatric Diseases by combining diverse types of clinical data i.e. neuroimaging, molecular data, clinical records and/or questionnaires as well as data covering social aspects of these diseases including subjective wellbeing are eligible.

Consortia must be international. They must involve at least 3 partners requesting funding from 3 participating countries, or 2 partners requesting funding from 2 participating countries and a partner from another country securing its own funding as a Flagship Core Project partner

Date de clôture :
19/04/2021


Institution :
Horizon Europe

Towards a molecular and neurological understanding of mental health and mental illness for the benefit of citizens and patients

Topic 1.2 Towards a molecular and neurological understanding of mental health and mental illness for the benefit of citizens and patients

Year of the topic: 2021

Action type: RIA

Expected outcomes:

  • Significantly advance the molecular and neurological understanding of how genetic, epigenetic and environmental risk factors interact and how and when psychosocial experiences become biologically embedded to drive the transition from mental health to mental illness
  • Identify and validate to the extent possible biomarkers for at least one of the following purposes and adoption in clinical settings:
    • development of quantitative, clinical measures of mental health
    • identification of genetic and epigenetic blueprints conferring susceptibility to and protection against mental illnesses, including also (pre)-disease signatures
    • establishment of more objective diagnostic and monitoring criteria (complementing current symptom-based criteria) to improve patient outcomes and reduce the stigma associated with mental illness
  • prediction of treatment response for better and more scientifically-guided use of currently available interventions
  • Discover new disease pathways and drug targets that have the potential to lead to the development of new classes of safer and more effective medications for the prevention and treatment of mental disorders , thus stimulating innovations within the European pharmaceutical industry and enabling it to become a global leader in the mental healthcare field
  • Investigate on a molecular and neurological level the effects of other non-pharmacological preventive strategies for the development and adoption of international clinical guidelines, best practices and policy recommendations
  • Establish recommendations for a person-centred and timely prevention of mental disorders , enhancing citizens´ trust, engagement and adherence to effective, evidence-based strategies for mental health promotion

Date de clôture :
2021

Latest publications

All publications

Disruption of conscious access in psychosis is associated with altered structural brain connectivity.

Berkovitch, Lucie et al.
https://pubmed.ncbi.nlm.nih.gov/33229501/

The Journal of neuroscience : the official journal of the Society for Neuroscience, JN-RM-0945-20. 26 Nov. 2020, doi:10.1523/JNEUROSCI.0945-20.2020

Towards precision medicine: What are the stratification hypotheses to identify homogeneous inflammatory subgroups.

Ioannou, M et al.
https://pubmed.ncbi.nlm.nih.gov/33189523/

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, S0924-977X(20)30934-2. 11 Nov. 2020, doi:10.1016/j.euroneuro.2020.11.001

A Brain Capital Grand Strategy: toward economic reimagination.

Smith, Erin et al.
https://pubmed.ncbi.nlm.nih.gov/33100330/

Molecular psychiatry, 10.1038/s41380-020-00918-w. 26 Oct. 2020, doi:10.1038/s41380-020-00918-w

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